연구진

  • 연구진

제3그룹

이명식 교수순천향대학교 의과대학 내과학교실

주요 연구 키워드

  • NASH
  • 대사질환

  • - 순천향대학교 의생명융합학과 석좌교수

    - 대한면역학회장

    - 대한민국학술원 종신회원

    - 연세대학교 의과대학 내분비내과 교수

    - 성균관대학교 의과대학 내과 교수

    - 삼성의료원 내분비대사내과 과장

    - 원자력병원 핵의학과장

     

  • 1. Impaired TFEB activation and mitophagy as a cause of PPP3/calcineurin inhibitor-induced pancreatic β-cell dysfunction. Autophagy (1-15), 2022

     

    2. Essential role of lysosomal Ca2+-mediated TFEB activation in mitophagy and functional adaptation of pancreatic β-cells to metabolic stress. Autophagy 18(12):3043-3045), 2022

     

    3. Park K, Lim H, Kim J, Hwang Y, Lee YS, Bae SH, Kim H, Kang SW, Kim JY, Lee M-S. Lysososmal Ca2+-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic b-cells to metabolic stress. Nat Commun, in press, 2022

     

    4. Kim J, Kim SH, Kang H, Lee S, Park S-Y, Cho Y, Lim Y-M, Ahn JW, Kim Y-H, Chung S, Choi CS, Jang YJ, Park HS, Heo Y, Kim KH, Lee M-S. TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response. Nat Metab 3:410-427, 2021

     

    5. Kim J, Park K, Kim MJ, Lim H, Kim KH, Kim S-W, Lee E-S, Kim H, Kim SJ, Hur KY, Kim JH, Ahn JH, Yoon K-H, Lee M-S. An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer. Nat Commun 12:183, 2021

     

    6. Lim H, Lim Y-M, Kim KH, Jeon YE, Park K, Kim J, Hwang HY, Lee DJ, Pagire H, Kwon HJ, Ahn JH, Lee M-S. A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes. Nat Commun 9:1438, 2018

     

    7. Kim J, Cheon H, Jeong YT, Quan W, Kim KH, Cho JM, Lim Y-M, Oh SH, Jin S-M, Kim JH, Lee M-K, Kim S, Komatsu M, Kang S-W, Lee M-S. Amyloidogenic peptide oligomer accumulation in autophagy-deficient beta cells leads to diabetes. J Clin Invest 114:3311-3324, 2014

     

    8. Lim Y-M, Lim HJ, Hur KY, Quan W, Lee H-Y, Cheon H, Ryu D, Koo S-H, Kim HL, Kim J, Komatsu M, Lee M-S. Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes. Nat Commun 5:4934, 2014

     

    9. Shin N-R, Lee J-C, Lee Y-Y, Kim M-S, Whon TW, Lee M-S, Bae J-W. (Co-correspondence) An increase in the Akkermansia sp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut 63:727-735, 2014

     

    10. Kim KH, Jeong YT, Oh H, Kim S-H, Cho JM, Kim Y-N, Kim SS, Kim D-H, Hur KY, Kim HK, Koh T, Han J, Kim H, Kim J, Back SH, Komatsu M, Chen H, Chan DC, Konishi M, Itoh N, Choi CS, Lee M-S. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing FGF21, a ‘mitokine’. Nature Medicine 19:83-92, 2013

     

    11. Jung H-S, Chung KW, Kim JW, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon K-H, Kim J-W, Jeong YT, Han MS, Lee M-K, Kim K-W, Shin J, Lee M-S. Loss of autophagy diminishes pancreatic β-cell mass and function with resultant hyperglycemia. Cell Metab 8:318-324, 2008

     

    12. Kim HS, Han MS, Chung KW, Kim S, Kim E, Kim MJ, Jang E, Lee HA, Youn J, Akira S, Lee M-S. Toll-like receptor 2 senses b-cell death and contributes to the initiation of autoimmune diabetes. Immunity 27:321-333, 2007

     

  • - Nat. Med, Cell Metab. 등 100편 이상 국제학술논문 게재

    - 대사질환 국내 최고 전문가(microbiota 대사 관련 Akkermansia의 대사증후군 개선 효과 최초 보고(800회 이상 인용)

    - High-fat diet의 대사이상 / gut permeability 연관성 보고

    - Gut immunity / immune response 전문가

    - MUP-uPA 마우스(NASH model) 제조자(Michael Karin)외 유일 보유

     

  • - 면역학회 학술 공로상

    - 아산의학 본상

    - 분쉬의학상