연구진

  • 연구진

제2그룹

류성호 교수 (2그룹책임)순천향대학교 의과대학 병리학교실

주요 연구 키워드

  • 다중오믹스
  • 엑소좀
  • 진단기술
  • - 뉴욕대 생물정보학 박사(NGS 분석, PhD)

    - 코넬대 종양학 Post Doc(암전이 연구)

    - 한국생명정보학회 부회장

    - 한국통합생물학회 이사

    - 미국국제암학회(AACR) 회원

    - 한국분자세포생물학회 정회원

    - 한국유전체학회 정회원

     

  • 1. Javaria Munir, Jeong Kyo Yoon, Seongho Ryu*, Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects. Cells. 2020 Oct 11;9(10):2271. (*Corresponding author)

     

    2. Hyoshik Kim, Yun-Ui Bae, Haekyung Lee, Hyoungnae Kim, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Dong Won Byun, Sang Hyun Kim, Hyeong Kyu Park, Seongho Ryu*, Soon Hyo Kwon, Effect of diabetes on exosomal miRNA profile in patients with obesity. BMJ Open Diabetes Res Care. 2020 Sep;8(1):e001403. (*Corresponding author)

     

    3. Jin Seok Jeon, Eunbit Kim, Yun-Ui Bae, Won Mi Yang, Haekyung Lee, Hyoungnae Kim, Hyunjin Noh, Dong Cheol Han, Seongho Ryu*, Soon Hyo Kwon*. microRNA in Extracellular Vesicles Released by Damaged Podocytes Promote Apoptosis of Renal Tubular Epithelial Cells. Cells. 2020 Jun 5;9(6):E1409. (*Corresponding author).

     

    4. Young Sok Ji, Seong Kyu Park, Seongho Ryu*. Whole Leukemia Cell Vaccines: Past Progress and Future Directions. Vaccine. 2020 May 8;38(22):3811-3820. (*Corresponding author).

     

    5. Javaria Munir, Trinh Van Ngu, Penchatr Diskul Na Ayudthaya, Seongho Ryu*. Downregulation of glypican-4 Facilitates Breast Cancer Progression by Inducing Cell Migration and Proliferation. Biochemical and Biophysical Research Communication. 2020 May 21;526(1):91-97. (*Corresponding author).

     

    6. Shira Yomtoubian, Sharrell B Lee, Akanksha Verma, Franco Izzo, Geoffrey Markowitz, Hyejin Choi, Leandro Cerchietti, Linda Vahdat, Kristy A Brown, Eleni Andreopoulou, Olivier Elemento, Jenny Chang, Giorgio Inghirami, Dingcheng Gao, Seongho Ryu*, Vivek Mittal*. Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer. Cell Reports. 2020 Jan 21;30(3):755-770.e6. (*Corresponding author)

     

    7. Javaria Munir, Mihye Lee, Seongho Ryu*. Exosomes in Food: Health Benefits and Clinical Relevance in Diseases. Advances in Nutrients. 2020 May 1;11(3):687-696. (*Corresponding author).

     

    8. Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in TripleNegative Breast Cancer (2020, Cell Reports)

     

    9. Exosomes in Food: Health Benefits and Clinical Relevance in Diseases (2019, Advances in Nutrition)

     

    10. Cheol-Ho Hyun, Heesoo Kim, Seongho Ryu*, Won Kim*. Preliminary Study on Microeukaryotic Community Analysis Using NGS Technology to Determine Postmortem Submersion Interval (PMSI) in the Drowned Pig. Journal of Microbiology. 2019 Nov;57(11):1003-1011. (*Corresponding author)

     

    11. Hyoungnae Kim, Yun-Ui Bae, Jin Seok Jeon, Hyunjin Noh, Hyeong Kyu Park, Dong Won Byun, Dong Cheol Han, Seongho Ryu*, Soon Hyo Kwon*. The Circulating Exosomal microRNAs Related to Albuminuria in Patients With Diabetic Nephropathy. Journal of Translational Medicine. 2019 Jul 22;17(1):236. (*Corresponding author)

     

    12. Yun-Ui Bae, Yongjin Kim, Haekyung Lee, Hyoungnae Kim, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Seongho Ryu*, Soon Hyo Kwon*. Bariatric Surgery Alters microRNA Content of Circulating Exosomes in Patients With Obesity. Obesity. 2019 Feb;27(2):264-271. (*Corresponding author)

     

    13. Cheolwon Choi , Seulgi Yoon , Hyesu Moon, Yun-Ui Bae, Chae-Bin Kim, Penchatr Diskul-Na-Ayudthaya, Trinh Van Ngu, Javaria Munir, JaeWook Han, Se Bin Park, Jong-Seok Moon, Sujung Song, Seongho Ryu*. mirRICH, a Simple Method to Enrich the Small RNA Fraction From Over-Dried RNA Pellets. RNA Biology. 2018 15(6):763-772. (*Corresponding author).

     

    14. Choi C, Thi Thao Tran N, Van Ngu T, Park SW, Song MS, Kim SH, Bae YU, Ayudthaya PDN, Munir J, Kim E, Baek MJ, Song S, Ryu S*, Nam KH*. Promotion of tumor progression and cancer stemness by MUC15 in thyroid cancer via the GPCR/ERK and integrin-FAK signaling pathways. Oncogenesis. 2018 12;7(11):85. (*Corresponding author)

     

    15. Cheolwon Choi, James Han, Nguyen Thi Thao Tran, Seulgi Yoon, Goeun Kim, Sujung Song, Youngjo Kim, Seongho Ryu*. Effective Experimental Validation of miRNA Targets Using an Improved Linker Reporter Assay. Genetic Research 2017 Jan 30;99:e2.

     

    16. Hyundoo Hwang, Changsik Shin, Juhee Park, Enoch Kang, Bongseo Choi, Jae-A Han, Yoonkyung Do, Seongho Ryu*, Yoon-Kyoung Cho*. Human breast cancer-derived soluble factors facilitate CCL19-induced chemotaxis of human dendritic cells. Scientific Reports 2016 Jul 25: 6:30207. (*Corresponding author)

     

    17. Bongseo Choi, Hyojin Moon, Sung Joon Hong, Changsik Shin, Yoonkyung Do, Seongho Ryu* , Sebyung Kang*. Effective Delivery of Antigen-Encapsulin Nanoparticle Fusions to Dendritic Cells Leads to Antigen-Specific Cytotoxic T Cell Activation and Tumor Rejection. ACS Nano. 2016 Jul 8, 10:7339-7350. (*Corresponding author)

     

    18. Changsik Shin, Han JA, Choi B, Cho YK, Do Y, Seongho Ryu*. Intrinsic features of the CD8- dendritic cell subset in inducing functional T follicular helper cells. Immunol Letters. 2016 Apr 2;172:21-28. (*Corresponding author).

     

    19. Fischer KR, Durrans A, Lee S, Sheng J, Li F, Wong ST, Choi H, El Rayes T, Seongho Ryu, Troeger J, Schwabe RF, Vahdat LT, Altorki NK, Mittal V, Gao D. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature. 2015 Nov 26;527(7579):472-6.

     

    20. Changsik Shin, Jae-A Han, Hyein Koh, Bongseo Choi, Yongbin Cho, Hyeongmin Jeong, Jea-Sun Ra, Pil Soo Sung, Eui-Cheol Shin, Seongho Ryu*, Yoonkyung Do*. CD8(-) Dendritic Cells Induce Antigen-Specific T Follicular Helper Cells Generating Efficient Humoral Immune Responses. Cell Reports. (2015) Jul 30;11(12):1929-40. (*Corresponding author)

     

    21. Seongho Ryu, Kevin McDonnell, Hyejin Choi, Dingcheng Gao, Mary Hahn, Natasha Joshi, Sun Mi Park, Raul Catena, Yoonkyung Do, Jacqueline Brazin, Linda T. Vahdat, Randi B. Silver, and Vivek Mittal. Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration. Cancer Cell (2013) 23:63-76. (*First author).

     

     

     

  • - 의료IT 기반 RNA 융합연구센터 구축_총괄책임/센터장_총 30억

    - 다중오믹스 기반 정밀의료기술개발사업_총괄책임_총 120억

    - miRNA의 표적 유전자 검증용 DNA 구조체 개발

    - 휴대용 RT-PCR기기

    - 대장암 진단용 마커 miRNA 조성물 특허

     

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